Influence of arsenate and arsenite on signal transduction pathways: an update
نویسندگان
چکیده
منابع مشابه
Update on Signal Transduction
Plants take up inorganic nitrogen (N) primarily as nitrate but also to a lesser extent as ammonium. Nitrate is reduced to nitrite in the cytoplasm by the highly regulated enzyme nitrate reductase. Nitrite is transported into the chloroplast and further reduced by nitrite reductase to ammonium. Ammonium is assimilated into the amino acid pool by the coordinate action of Gln synthetase (GS) and G...
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متن کاملTpl2 is a key mediator of arsenite-induced signal transduction.
Arsenite is a well-known human carcinogen that especially targets skin. The tumor progression locus 2 (Tpl2) gene encodes a serine/threonine protein kinase that is overexpressed in various cancer cells. However, the relevance of Tpl2 in arsenite-induced carcinogenesis and the underlying mechanisms remain to be explored. We show that arsenite increased Tpl2 kinase activity and its phosphorylatio...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2010
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-010-0554-4